The winery is located in the municipality of Moulis (Moulis-en-Médoc) around the area of the same name in the Médoc (Haut-Médoc, Bordeaux). In the Bordeaux classification according to the old system, which is no longer valid, it was last classified as "Cru Bourgeois Exceptionnel" in 2003. Until the beginning of the 19th century, the Gressier family owned vineyards called Grand-Poujeaux. The extensive property was acquired by the merchant André Castaing in 1806. In 1820, the first division of the inheritance took place, which subsequently resulted in Château Gressier Grand-Poujeaux, Château Maucaillou and Château Poujeaux.
Another part of the inheritance consisted of an at that time nameless part. When this was divided up again in 1860, a name had to be found. Allegedly this name was derived from a quotation of the famous English poet Lord Byron (1788-1824). During a visit to Bordeaux, the very melancholic artist made the acquaintance of the Moulis wine, suddenly felt better after drinking it and free of all his worries and coined the term "getting rid of the blues" (French: "chasser le spleen", meaning "to scare away bad moods"). Another version, however, attributes the origin of the name to the French writer Charles-Pierre Baudelaire (1821-1867), who was on vacation in the vicinity. One of the themes of his famous collection of poems "Les Fleurs du Mal" was called "Spleen et Ideal".
After the end of the Castaing-era in 1909, there were several changes of ownership and the decline due to phylloxera, World War II and economic problems. In the mid-1970s, the estate was acquired by the Taillan Group under the management of Jacques Merlaut (+2008). His daughter Bernadette Villars successfully revived the estate. After her tragic death, it has been managed by her daughter Claire Villars-Lurton since 1992. The vineyards cover 72 hectares and are planted with Cabernet Sauvignon (50%), Merlot (45%), Petit Verdot (3%) and Cabernet Franc (2%). The long-lasting red wine matures up to 24 months in 50% new barriques. The second wines are called "L'Ermitage de Chasse-Spleen" and "L'Oratoire de Chasse-Spleen".